Feline Hyperthyroidism: Advances Towards Novel Molecular Therapeutics

Blackwood L. and Argyle D.J.

J Small Anim Pract, 2002. 43(2): p.58-66.


Feline hyperthyroidism is the most common endocrine disorder of the elderly cat. Traditionally, the disease is treated by surgical thyroidectomy, medical management with antithyroid drugs or radiation therapy using iodine-131. However, none of these treatments is ideal and molecular therapeutics may offer novel methods of treating the disease. This article reviews the background of, and preliminary investigations into, the development of a transcriptionally targeted somatic gene therapy strategy for the treatment of this feline condition.